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J Interferon Cytokine Res. 1995 Dec;15(12):1061-4.

Serum interleukin-6 levels in the steady state of sickle cell disease.

Author information

1
Department of Pediatrics, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA.

Abstract

In patients with childhood sickle cell disease (SCD) serum interleukin-6 (IL-6) levels were measured during the steady (healthy) state of disease. The corresponding measurements were made in comparable healthy normal controls. Serum IL-6 levels were assessed via ELISA in 27 SCD patients and 19 controls. Results revealed significantly higher circulating levels of IL-6 in the SCD patients (60 +/- 7 pg/ml) compared with the healthy controls (12 +/- 5 pg/ml). IL-6 is a multifunctional cytokine that plays a central role in host defense mechanisms. The impact of high circulating levels of IL-6 may be deleterious to humoral and cell-mediated immune functions in SCD, with resultant heightened risk for morbidity.

PMID:
8746787
DOI:
10.1089/jir.1995.15.1061
[Indexed for MEDLINE]

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