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Curr Opin Cell Biol. 1996 Jun;8(3):389-96.

Synaptonemal complexes: structure and function.

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Department of Genetics, Agricultural University, Wageningen, The Netherlands. Christa.Heyting@MolCelGen.ELWAU.NL


Synaptonemal complexes (SCs) are zipper-like structures which are assembled between homologous chromosomes during the prophase of the first meiotic division. Their assembly and disassembly correlate with the successive chromatin rearrangements of meiotic prophase, namely the condensation, pairing, recombination and disjunction of homologous chromosomes. It was originally thought that SCs created the preconditions for the homologous crossing over of chromosomes by bringing corresponding parts of homologous chromosomes in close apposition. However, this view has been gradually undermined during recent years, and ideas about the roles of SCs have radically changed. SCs are now considered to be structures that both control the number and distribution of reciprocal exchanges between homologous chromosomes (cross-overs) and convert cross-overs into functional chiasmata. How SCs fulfil these roles remains to be elucidated.

[Indexed for MEDLINE]

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