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Curr Opin Cell Biol. 1996 Jun;8(3):381-8.

Kinetochore function: molecular motors, switches and gates.

Author information

1
Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, USA. TJ.Yen@fccc.edu

Abstract

Kinetochores are essential for accurate chromosome segregation. Recent studies reveal that vertebrate kinetochores are sophisticated propulsion systems composed of not only force generators but also "navigation' and "fail-safe' mechanisms. Advances toward the understanding of the biochemical composition and activities of the components of the kinetochore have come from the molecular characterization of key proteins of the kinetochore complex.

PMID:
8743891
DOI:
10.1016/s0955-0674(96)80014-7
[Indexed for MEDLINE]

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