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Curr Opin Cell Biol. 1996 Jun;8(3):369-73.

Nucleosome assembly: the CAF and the HAT.

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Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.


Recent data argue strongly that a protein complex termed chromatin assembly factor-1 (CAF-I) plays a major role in de novo nucleosome assembly during DNA replication. Human CAF-I deposits newly synthesized, acetylated histones onto replicated DNA in vitro and localizes to sites of DNA replication in S-phase cells. Specific lysines of the histones used for nucleosome assembly are acetylated; in the past year the first gene encoding a histone acetyltransferase was cloned. However, mechanistic links between histone acetylation and nucleosome assembly have not been established in vivo or in vitro.

[Indexed for MEDLINE]

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