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Curr Opin Cell Biol. 1996 Jun;8(3):348-53.

Imprinted genes and regulation of gene expression by epigenetic inheritance.

Author information

1
Wellcome/CRC Institute of Cancer and Developmental Biology, Cambridge, UK. rmj22@cus.cam.ac.uk

Abstract

Six new imprinted genes have recently been identified by association with established imprinted regions, in systematic screens or by serendipity. This brings the total to seventeen imprinted genes, which display a wide variety of functions. Some imprinted genes have been shown to be both physically and mechanistically linked within domains that are under the control of an imprinting centre. Others may apparently undergo imprinting independently. Methylation is clearly required for maintenance of mono-allelic expression while chromatin structure and non-coding RNAs may also play a role.

PMID:
8743885
DOI:
10.1016/s0955-0674(96)80008-1
[Indexed for MEDLINE]

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