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Curr Opin Cell Biol. 1996 Jun;8(3):303-11.

Mechanisms of transcription complex assembly.

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Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park 16802, USA.


Gene-specific activators control the access of RNA polymerase II (pol II) to promoters in several ways: by chromatin rearrangement involving an ATP-dependent SWI-SNF complex; by the synergistic recruitment of transcription factor IID (TFIID); and by either the sequential recruitment of basal transcription factors and pol II or the recruitment of a preformed pol II holoenzyme which includes most of the basal factors. One of the most significant recent developments has been the demonstration that distinct subunits of TFIID (namely subunits of the TATA-binding protein associated factor) target different activators, basal factors, and core promoter elements.

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