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J Struct Biol. 1996 Jan-Feb;116(1):209-15.

Automated software package for icosahedral virus reconstruction.

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Verna and Marrs McLean Department of Biochemistry and W. M. Keck Center for Computational Biology, Baylor College of Medicine, Houston, Texas 77030, USA.


The three-dimensional reconstruction of icosahedral viruses from electron micrograph images has become an important tool for understanding virus structure, function, and pathogenesis. We have developed an integrated suite of software programs to automate most of the operations involved in producing these reconstructions from EM images. Our package combines the analytical capabilities of preexisting algorithms together with approaches we have developed to produce an interactive working environment which enhances the efficiency and usefulness of this approach to the structural analysis of icosahedral viruses.

[Indexed for MEDLINE]

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