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Am J Med Genet. 1996 Jan 22;61(3):264-8.

Blood group chimerism in human multiple births is not rare.

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1
Blood Transfusion Department, University Hospital St. Radboud, Nijmegen, Netherlands.

Abstract

Twin blood group chimerism seems to be very rare in humans. The 30-40 previously reported cases usually were found by mere coincidence during routine blood grouping in hospitals or blood banks. Usually in these cases frank blood group mixtures of, for example, 50/50%, 25/75%, or 5/95% at most were seen. Smaller percentages are very difficult to notice during routine work-up. Using a sensitive fluorescence technique (sensitivity > 0.01%) we detected blood group chimerism in 32/415 (8%) twin pairs and 12/57 (21%) triplet pairs, respectively, which is a higher incidence than reported previously.

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