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Int J Dermatol. 1996 Jun;35(6):448-9.

Oil of bitter orange: new topical antifungal agent.

Author information

1
Department of Dermatology and Venereology, Faculty of Medicine, Tanta University, Egypt.

Abstract

BACKGROUND:

Superficial dermatophyte infection is one of the most common dermatologic diseases. Some of these infections are extremely resistant to therapy.

METHODS AND PATIENTS:

Sixty patients participated in this study; they were classified into three groups (20 patients in each). All groups had comparable numbers of patients with tinea corporis, cruris, and pedis. Group 1 was treated with a 25% emulsion of oil of bitter orange (OBO) three times daily; group 2 was treated with 20% OBO in alcohol three times daily and group 3 was treated with pure OBO, once daily. Clinical and mycologic examinations were performed before therapy and every week until a complete cure had occurred.

RESULTS:

In group 1, 80% of patients were cured in 1 to 2 weeks and 20% in 2 to 3 weeks. In group 2, 50% were cured in 1 to 2 weeks, 30% in 2 to 3 weeks and 20% in 3 to 4 weeks. In group 3, 25% of patients did not continue the trial. Of the remaining patients, 33.3% were cured in one week, 60% in 1 to 2 weeks, and 6.7% in 2 to 3 weeks. Oil of bitter orange produced no side effects except mild irritation seen with the use of the pure form.

CONCLUSIONS:

An in vitro study showed that OBO (natural product) exerts fungistatic and fungicidal activity against a variety of pathogenic dermatophyte species. It is a promising, cheap, and available topical antifungal therapeutic agent.

PMID:
8737885
[Indexed for MEDLINE]

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