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Eur J Clin Pharmacol. 1996;50(3):241-4.

Stereoselective pharmacokinetics of mefloquine in young children.

Author information

1
Hôpital Pitie Salpetriere Service Pharmacie 47, Paris, France.

Abstract

OBJECTIVE:

the stereospecificity of mefloquine pharmacokinetics in children has been investigated.

PATIENTS:

Twelve children aged 6 to 24 months were treated for uncomplicated falciparum malaria with a single oral dose of 25 mg.kg-1 racemic mefloquine in combination with sulfadoxine and pyrimethamine.

METHODS:

concentrations of mefloquine enantiomers were determined using a coupled achiral-chiral chromatographic system. Pharmacokinetic parameters were calculated using model-independent analysis.

RESULTS:

Maximum plasma concentrations, areas under the curve and apparent plasma elimination half-lives were higher for the (-) enantiomer than its antipode. In contrast, the apparent volume of distribution (V/f) and total clearance (Cl/f) values were higher for the (+) enantiomer.

CONCLUSION:

the stereoselectivity of mefloquine pharmacokinetics is similar to that observed in adults.

PMID:
8737767
DOI:
10.1007/s002280050100
[Indexed for MEDLINE]

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