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Neurosci Lett. 1996 May 3;209(1):49-52.

Hippocampal slices from prion protein null mice: disrupted Ca(2+)-activated K+ currents.

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1
Department of Physiology and Biophysics, St Mary's Hospital Medical School, Imperial College, London, UK.

Abstract

The intrinsic properties of hippocampal CA1 pyramidal cells were examined in mice lacking prion protein (PrP-null). The resting potentials, time constants, amplitude of the medium afterhyperpolarization (AHP) and spike firing accommodation did not differ from the control group. The PrP-null group differed in having lower input resistances, a lack of the late AHP and of a charybdotoxin-sensitive summated AHP. We propose that CA(2+)-activated K+ currents, in particular IAHP, are disrupted in PrP-null mice.

PMID:
8734907
[Indexed for MEDLINE]
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