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Mech Dev. 1996 Mar;55(1):53-64.

huckebein is required for glial development and axon pathfinding in the neuroblast 1-1 and neuroblast 2-2 lineages in the Drosophila central nervous system.

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1
Institut für Genetik, Universität Mainz, Germany.

Abstract

huckebein encodes a predicted zinc finger transcription factor which is transiently expressed in a subset of Drosophila central nervous system precursors (neuroblasts (NBs)). We used DiI cell lineage tracing and cell fate markers to investigate the role of huckebein in the NB 1-1 and NB 2-2 cell lineages. Loss of huckebein does not switch these NBs into different NB fates, nor does it change the number of cells in their lineages; rather, it is required for glial development in the NB 1-1 lineage, and for axon pathfinding of a subset of interneurons and motoneurons in both lineages.

PMID:
8734499
DOI:
10.1016/0925-4773(95)00490-4
[Indexed for MEDLINE]
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