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Neurosci Lett. 1996 Apr 12;208(1):1-4.

Nitric oxide induces cultured cortical neuron apoptosis.

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1
URA-CNRS 1485, Faculté de Médecine et de Pharmacie de Limoges, France.

Abstract

A series of experiments were designed to examine the potential induction of apoptosis by nitric oxide (NO) donors on cortical neuronal cell culture. A 24 h exposure of three different NO donors, 3-morpholinosydnonimine, S-nitroso-N-acetyl-penicillamine, and S-nitrosoglutathione, induced apoptosis as indicated by following histological (cellular and nuclear morphology) and biochemical markers (DNA oligonucleosomal fragmentation and protection by protein synthesis inhibitor).

PMID:
8731160
[Indexed for MEDLINE]
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