Abstract
Appetitive behaviors of rats were monitored in a runway situation following central infusions of neuroactive substances into brain areas implicated in electrical self-stimulation. Microinjections of the dopamine antagonist cis-flupentixol or the cholinergic antagonist atropine into the nucleus accumbens (Acb) severely reduced the approach speed and anticipatory shuttlebox activity while leaving the consumption of the 20% sucrose reward intact. Microinjections of GABA into the ventral tegmental area (VTA), pedunculopontine tegmental nucleus (PPTg), and oral pontine reticular nucleus (PnO) also severely disrupted approach without decreasing consumption. The highest doses of atropine into the VTA, PPTg, and PnO disrupted both consummatory and approach responses equally. The results indicate that modulation of various neurochemistries along the trajectory of the self-stimulation system has stronger effects on appetitive approach than consummatory motivation. The implications for understanding appetitive-approach motivation in the brain are discussed.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acetylcholine / physiology
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Animals
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Appetitive Behavior / drug effects
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Appetitive Behavior / physiology*
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Brain / drug effects
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Brain / physiology*
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Brain Mapping
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Consummatory Behavior / drug effects
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Consummatory Behavior / physiology*
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Dopamine Antagonists / pharmacology
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Electric Stimulation
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Flupenthixol / pharmacology
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Male
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Microinjections
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Motivation*
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Motor Activity / drug effects
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Motor Activity / physiology
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Neurotransmitter Agents / physiology*
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Nucleus Accumbens / drug effects
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Nucleus Accumbens / physiology
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Pons / drug effects
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Pons / physiology
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Rats
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Reticular Formation / drug effects
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Reticular Formation / physiology
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Self Stimulation / drug effects
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Self Stimulation / physiology*
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Tegmentum Mesencephali / drug effects
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Tegmentum Mesencephali / physiology
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Ventral Tegmental Area / drug effects
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Ventral Tegmental Area / physiology
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gamma-Aminobutyric Acid / pharmacology
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gamma-Aminobutyric Acid / physiology
Substances
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Dopamine Antagonists
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Neurotransmitter Agents
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gamma-Aminobutyric Acid
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Flupenthixol
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Acetylcholine