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Neuroscience. 1996 May;72(1):105-15.

Increased subthalamic neuronal activity after nigral dopaminergic lesion independent of disinhibition via the globus pallidus.

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1
Laboratoire de Pharmacologie, Faculté des Sciences Pharmaceutiques et Biologiques, Université R. Descartes, Paris, France.

Abstract

Electrophysiological records of unit activity were used to compare the effects of excitotoxic pallidal lesions and 6-hydroxydopamine-induced damage to the midbrain dopaminergic neurons on the discharge rates and patterns of the subthalamic neurons. Removal of the pallidal input induced a slight, but statistically significant, increase (19.5%) in the discharge rate and no change in the firing pattern when compared to control animals. The rats with a dopaminergic lesion showed greater increase (105.7%) while the firing pattern activity of the subthalamic neurons became more irregular, with burst. These results indicate that the increased activity of the subthalamic neurons following a midbrain dopaminergic lesion cannot be due solely to inhibition-disinhibition involving the striato-pallido-subthalamic pathway and induced by the striatal dopaminergic depletion.

PMID:
8730710
[Indexed for MEDLINE]

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