Abstract
Over the past year, several important advances have been made in understanding the mechanisms by which class II MHC glycoproteins acquire endosomal peptides inside antigen-presenting cells. Recent progress in the study of class II antigen presentation includes the identification of ligands from which invariant chain protects class II molecules in pre-endosomal compartments, an improved understanding of how invariant chain inhibits antigenic peptide binding, and the appreciation that HLA-DM (a factor important for antigen presentation in vivo) can act as a catalyst for peptide exchange.
MeSH terms
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Antigen Presentation*
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Antigens, Differentiation, B-Lymphocyte / immunology
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Antigens, Differentiation, B-Lymphocyte / metabolism
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Binding Sites
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Endosomes / immunology
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Endosomes / metabolism
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HLA-D Antigens / immunology
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HLA-D Antigens / metabolism
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Histocompatibility Antigens Class II / biosynthesis
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Histocompatibility Antigens Class II / chemistry
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Histocompatibility Antigens Class II / immunology
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Histocompatibility Antigens Class II / metabolism*
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Ligands
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Models, Immunological
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Protein Binding
Substances
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Antigens, Differentiation, B-Lymphocyte
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H2-M antigens
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HLA-D Antigens
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HLA-DM antigens
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Histocompatibility Antigens Class II
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Ligands
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invariant chain