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Curr Opin Immunol. 1996 Feb;8(1):51-8.

Developing and shedding inhibitions: how MHC class II molecules reach maturity.

Author information

1
Joseph Stokes Jr Research Institute, Children's Hospital of Philadelphia, PA 19104, USA.

Abstract

Over the past year, several important advances have been made in understanding the mechanisms by which class II MHC glycoproteins acquire endosomal peptides inside antigen-presenting cells. Recent progress in the study of class II antigen presentation includes the identification of ligands from which invariant chain protects class II molecules in pre-endosomal compartments, an improved understanding of how invariant chain inhibits antigenic peptide binding, and the appreciation that HLA-DM (a factor important for antigen presentation in vivo) can act as a catalyst for peptide exchange.

PMID:
8729446
DOI:
10.1016/s0952-7915(96)80105-1
[Indexed for MEDLINE]

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