Developing and shedding inhibitions: how MHC class II molecules reach maturity

Curr Opin Immunol. 1996 Feb;8(1):51-8. doi: 10.1016/s0952-7915(96)80105-1.

Abstract

Over the past year, several important advances have been made in understanding the mechanisms by which class II MHC glycoproteins acquire endosomal peptides inside antigen-presenting cells. Recent progress in the study of class II antigen presentation includes the identification of ligands from which invariant chain protects class II molecules in pre-endosomal compartments, an improved understanding of how invariant chain inhibits antigenic peptide binding, and the appreciation that HLA-DM (a factor important for antigen presentation in vivo) can act as a catalyst for peptide exchange.

Publication types

  • Review

MeSH terms

  • Antigen Presentation*
  • Antigens, Differentiation, B-Lymphocyte / immunology
  • Antigens, Differentiation, B-Lymphocyte / metabolism
  • Binding Sites
  • Endosomes / immunology
  • Endosomes / metabolism
  • HLA-D Antigens / immunology
  • HLA-D Antigens / metabolism
  • Histocompatibility Antigens Class II / biosynthesis
  • Histocompatibility Antigens Class II / chemistry
  • Histocompatibility Antigens Class II / immunology
  • Histocompatibility Antigens Class II / metabolism*
  • Ligands
  • Models, Immunological
  • Protein Binding

Substances

  • Antigens, Differentiation, B-Lymphocyte
  • H2-M antigens
  • HLA-D Antigens
  • HLA-DM antigens
  • Histocompatibility Antigens Class II
  • Ligands
  • invariant chain