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Curr Opin Immunol. 1996 Feb;8(1):36-40.

Mechanisms of phagocytosis.

Author information

1
Laboratory of Signal Transduction, Rockefeller University, New York, NY 10021, USA. allenl@rockvax.rockefeller.edu

Abstract

Recent advances in research on phagocytosis include a better appreciation of the cross-talk between phagocytic receptors, the definition of multiple signaling domains within these receptors, and a deeper understanding of the downstream effector pathways leading to actin polymerization and particle internalization. Phagosome maturation in macrophages proceeds via a series of membrane fusion and fission events, which modify the phagosome in small increments, and appears to be regulated, in part, by GTP-binding proteins and perhaps by protein kinase C. The isolation of dysphagic mutants of Dictyostelium discoideum presages the identification of new genes required for phagocytosis.

PMID:
8729444
DOI:
10.1016/s0952-7915(96)80102-6
[Indexed for MEDLINE]

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