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Curr Opin Immunol. 1996 Feb;8(1):20-8.

Scavenger receptors in innate immunity.

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Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA.


Scavenger receptors are cell-surface proteins expressed by mammalian monocytes and macrophages and by invertebrate hemocytes, among other cell types. They exhibit distinctive ligand-binding properties, recognizing a wide range of ligands that include microbial surface constituents and intact microbes. The ligand-binding properties and expression patterns of these receptors suggest that they may function in one or more host-defense-related processes. Significant advances in scavenger receptor biology have recently been reported, including the identification of several new scavenger receptor genes.

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