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Trends Microbiol. 1996 Apr;4(4):147-53.

Role of verotoxin receptors in pathogenesis.

Author information

1
Hospital for Sick Children, Dept of Microbiology, Toronto, Ontario, Canada.

Abstract

Verotoxin-globotriaosyl ceramide (Gb3) binding is the linchpin in disease induced by verotoxin-producing Escherichia coli (VTEC), and defines cell sensitivity, tissue tropism, mode of systemic transport, specific cytotoxic activity and internal routing within sensitive cells. Binding explains the epidemiology of renal pathology, which may follow VTEC infection. Lipid heterogeneity of Gb3 is important in binding, and may define a growth-related signal transduction pathway used by verotoxin.

PMID:
8728608
DOI:
10.1016/0966-842x(96)10017-2
[Indexed for MEDLINE]

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