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Trends Microbiol. 1996 Apr;4(4):135-41.

Running the gamut of retroviral variation.

Author information

1
Unité de Rétrovirologie Moléculaire, Institut Pasteur, Paris, France. simon@pasteur.fr

Abstract

The retroviral DNA polymerase, or reverse transcriptase, lacks a 3' exonuclease proofreading activity. This causes a high mutation rate with the result that genetic diversity and drug resistance are increased. Only combination chemotherapy has the potential to out-manoeuvre these viruses. However, there is no evidence that ongoing variation allows escape from immune surveillance, so contributing to pathogenesis.

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PMID:
8728606
DOI:
10.1016/0966-842x(96)10023-8
[Indexed for MEDLINE]

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