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Curr Opin Immunol. 1996 Apr;8(2):206-14.

The molecular basis of somatic hypermutation of immunoglobulin genes.

Author information

1
Department of Molecular Genetics and Cell Biology, University of Chicago, IL 60637, USA. stor@midway.uchicago.edu

Abstract

Somatic hypermutation amplifies the variable region repertoire of immunoglobulin genes. Recent experimental evidence has thrown light on various molecular models of somatic hypermutation. A link between somatic hypermutation and transcription coupled DNA repair is shaping up.

PMID:
8725944
DOI:
10.1016/s0952-7915(96)80059-8
[Indexed for MEDLINE]

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