Format

Send to

Choose Destination
See comment in PubMed Commons below
Neuroreport. 1996 Mar 22;7(4):847-52.

Host regulation of glial markers in intrastriatal grafts of conditionally immortalized neural stem cell lines.

Author information

  • 1Department of Medical Cell Research, University of Lund, Sweden.

Abstract

After transplantation into the adult CNS the immortalized neural stem cell lines ST14A and HiB5 differentiate preferentially into glia-like cells. After lesions of the host brain, which activate resting glial populations, the grafted cells responded with up-regulation of glial markers and a change in morphology towards a reactive state. The protein expression followed the same pattern as in the host glial population. The results show that the astrocytes formed by the grafted neural stem cells become functionally integrated in the host brain and that they may take an active part in the reactive gliosis caused by brain damage.

PMID:
8724658
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center