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Antimicrob Agents Chemother. 1996 May;40(5):1298-300.

Trophozoite elimination in a rat model of Pneumocystis carinii pneumonia by clinically achievable plasma deferoxamine concentrations.

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1
Department of Medical and Molecular Parasitology, New York University School of Medicine, New York 10016, USA.

Abstract

In a rat model of Pneumocystis carinii pneumonia, a 3-week infusion of deferoxamine producing concentrations in plasma of > or = 1.5 micrograms m-1 eliminated the trophozoite life cycle stage. Since this concentration is well below that routinely achieved in patients treated for iron overload, deferoxamine has promise as a therapy for AIDS-associated P.carinii pneumonia.

PMID:
8723489
PMCID:
PMC163314
[Indexed for MEDLINE]
Free PMC Article
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