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DNA Seq. 1996;6(3):171-4.

Significant divergence in nucleotide sequences for beta-tubulin from different laboratory strains of Chinese hamster ovary cells.

Author information

1
Department of Pharmacology, University of Texas Medical School, Houston 77225, USA.

Abstract

The nucleotide sequences for isotype 1 beta-tubulin cDNAs cloned from different laboratory strains of Chinese hamster ovary (CHO) cells were compared and found to contain an unexpected number of sequence differences in both translated and untranslated regions of the gene. The results indicate significant changes in the DNA, but not protein, sequence while the cells have been in culture and reveal sequences in the 5' and 3' untranslated regions that have resisted these changes.

PMID:
8722572
DOI:
10.3109/10425179609010205
[Indexed for MEDLINE]

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