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Curr Opin Genet Dev. 1996 Apr;6(2):185-92.

Boundary and insulator elements in chromosomes.

Author information

1
Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218, USA.

Abstract

Recent progress in understanding boundary and insulator elements has concentrated on the identification of their protein components. BEAF-32 is a protein present in the scs' element of Drosophila that is also localized to most interband regions and puffs of polytene chromosomes, suggesting a role in the organization of structural chromosomal domains. The suppressor of Hairy-wing and modifier of mdg4 proteins have been characterized as components of the gypsy insulator. The latter seems to play a crucial role in conferring on the insulator its ability to unidirectionally affect enhancer function.

PMID:
8722175
DOI:
10.1016/s0959-437x(96)80049-9
[Indexed for MEDLINE]

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