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Curr Opin Genet Dev. 1996 Apr;6(2):164-70.

Regulation of gene expression by nucleosomes.

Author information

1
Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110-1093, USA.

Abstract

During the past year, the characterization of mechanisms and factors capable of disrupting nucleosomes during transcriptional activation has been a recurrent theme in studies which address the contribution of nucleosome structure to gene regulation. In vivo studies using yeast and Drosophila together with biochemical purification schemes using nucleosome perturbation assays have provided evidence for the existence of multiprotein complexes that are able to alleviate nucleosome repression. At the same time, new insights into the mechanism of heterochromatin formation have been gained, which have direct links to nucleosome structure.

PMID:
8722172
DOI:
10.1016/s0959-437x(96)80046-3
[Indexed for MEDLINE]

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