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Curr Opin Genet Dev. 1996 Apr;6(2):146-50.

DNA repair and transcription.

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Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75235, USA.


The transcription factor TFIIH continues to be a subject of interest. In addition to its function as a repair and transcription factor, TFIIH includes a cyclin-dependent kinase and a cyclin, which raises the possibility that nucleotide excision repair (NER), RNA polymerase II transcription and cell cycle control are connected. Progress in mechanistic studies of NER include the identification of dual incision activities operating on either side of base damage and the isolation of a repairosome supercomplex in yeast. Additionally, NER has been demonstrated in reconstituted human and yeast systems, both of which include TFIIH.

[Indexed for MEDLINE]

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