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Immunol Res. 1995;14(4):271-91.

Regulatory mechanisms of antitumor T cell responses in the tumor-bearing state.

Author information

1
Biomedical Research Center, Osaka University Medical School, Japan.

Abstract

Tumor-bearing hosts develop antitumor immune responses. However, a number of immunosuppressive mechanisms come into operation with the progression of tumor growth. This article will review the observations regarding the modulation of antitumor immune responses in the tumor-bearing state, and consider the mechanisms underlying tumor-induced immune defects, especially in the light of the induction of an abnormal cytokine network. We will also describe the restoration of suppressed antitumor immune responses by administration of a particular cytokine, interleukin-12.

PMID:
8722044
DOI:
10.1007/bf02935625
[Indexed for MEDLINE]

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