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Biochem Cell Biol. 1995 Nov-Dec;73(11-12):1141-9.

The accuracy center of a eukaryotic ribosome.

Author information

1
Department of Biological Sciences, University of Illinois at Chicago, USA.

Abstract

Mutations in yeast ribosomal proteins and ribosomal RNAs have been shown to affect translational fidelity. These mutations include: proteins homologous to Escherichia coli's S4, S5, and S12; a eukaryote specific ribosomal protein; yeast ribosomal rRNA alterations at positions corresponding to 517, 912, and 1054 in 16S E. coli rRNA and to 2658 in the sarcin-ricin domain of 23S E. coli rRNA. Overall there appears to be a remarkable conservation of the accuracy center throughout evolution.

PMID:
8722031
DOI:
10.1139/o95-123
[Indexed for MEDLINE]

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