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Cell Mol Neurobiol. 1995 Dec;15(6):653-73.

Galanin--a neuropeptide with inhibitory actions.

Author information

1
Department of Neurochemistry and Neurotoxicology, Stockholm University, Sweden.

Abstract

1. Galanin is a 29 (in humans 30) amino acids long neuropeptide with mostly inhibitory, hyperpolarizing actions. 2. Differential structural requirements of truncated forms of galanin and differential agonist/antagonist behaviour of chimeric peptides, high affinity galanin receptor ligands suggest the presence of pharmacologically distinct galanin receptor subtypes. 3. The galanin receptor from human Bowes melanoma cell line--a member of G-protein coupled receptor superfamily--has been cloned. 4. Galanin acts via Gi/G(o) proteins inhibiting cAMP production, inositol phosphate turnover, opening K+ channels or closing Ca2+ channels.

PMID:
8719035
DOI:
10.1007/bf02071130
[Indexed for MEDLINE]

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