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Annu Rev Med. 1996;47:47-56.

How does lithium work on manic depression? Clinical and psychological correlates of the inositol theory.

Author information

1
Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel.

Abstract

How lithium works in manic-depressive illness is unknown. Recently, however, a powerful hypothesis has been gaining momentum. Distinguished by its testability and clinical implications, the inositol depletion hypothesis of lithium action is relevant to treatment of lithium side effects, to the development of new compounds with the clinical profile of lithium, and to new experimental treatment of depression.

PMID:
8712796
DOI:
10.1146/annurev.med.47.1.47
[Indexed for MEDLINE]

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