Format

Send to

Choose Destination
Annu Rev Med. 1996;47:285-301.

Clinical implications of the p53 gene.

Author information

1
Johns Hopkins University School of Medicine, Department of Otolaryngology, Baltimore, Maryland 21205-2196, USA.

Abstract

The capacity for malignant growth is acquired by the stepwise accumulation of defects in specific genes regulating cell growth and tissue homeostasis. Although several hundred genes are known to control growth, molecular genetic studies in cancer show that few of these are consistently involved in the natural history of human cancer, and those typically in only certain types of malignancy. Prospects for development of molecular-based diagnostic and therapeutic strategies with widespread application did not look promising, until it was realized that the p53 tumor suppressor gene was defective in approximately half of all malignancies. This discovery generated research efforts of unparalleled intensity to determine how p53 functions at the molecular level, and how to apply this knowledge to clinical ends.

PMID:
8712782
DOI:
10.1146/annurev.med.47.1.285
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center