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Semin Oncol. 1996 Jun;23(3 Suppl 7):15-8.

Ifosfamide-based chemotherapy for non-small cell lung cancer: phase I/II studies at the University of Chicago.

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1
Department of Medicine, University of Chicago, IL, USA.

Abstract

Current clinical investigations in the palliative care setting for patients with non-small cell lung cancer are focused on new drugs and combinations. The goal of these studies is to identify more effective and/or less toxic therapy. At the University of Chicago, we have conducted phase I and II studies to integrate new single agents into novel combination chemotherapy regimens. Two such studies have combined the use of ifosfamide with either vinorelbine or paclitaxel. All these drugs have established single-agent activity in non-small cell lung cancer and a favorable toxicity spectrum. We describe the study rationale and design, and the preliminary data of these trials.

PMID:
8711496
[Indexed for MEDLINE]
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