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Oncogene. 1996 Jul 18;13(2):223-35.

One billion years of Myb.

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Department of Pathology, Stanford University School of Medicine, California 94305-5324, USA.


The v-myb oncogene of the avian myeloblastosis virus has led to the discovery of a large and growing family of myb-related genes in a wide variety of eukaryotes including animals, plants, fungi and slime molds. The Myb-related proteins contain a highly conserved sequence, often present in multiple tandem repeats which constitute a DNA-binding domain. These proteins generally function in the regulation of cell growth and differentiation, often by coregulating gene expression along with DNA-binding proteins of other classes. This review focuses on the evolution of the myb gene family and the role of these genes in development.

[Indexed for MEDLINE]

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