Format

Send to

Choose Destination
See comment in PubMed Commons below
J Virol. 1996 Sep;70(9):6157-61.

Human immunodeficiency virus type 1 Nef associates with a member of the p21-activated kinase family.

Author information

1
Laboratory of Molecular Biology, National Institute of Mental Health, Bethesda, Maryland 20892, USA.

Abstract

Although human immunodeficiency virus (HIV) Nef is essential for the induction of AIDS, its biochemical function has remained an enigma. In this study, HIV Nef protein is shown to associate with a serine-threonine kinase that recognizes histone H4 as a substrate, is serologically related to rat p21-activated kinase (PAK), and is specifically activated by Rac and Cdc42. These characteristics define the Nef-associated kinase as belonging to the PAK family. PAKs initiate kinase cascades in response to environmental stimuli, and their identification as a target of Nef implicates these signaling molecules in HIV pathogenesis and provides a novel target for clinical intervention.

PMID:
8709241
PMCID:
PMC190639
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center