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J Pediatr. 1977 Jun;90(6):1019-21.

Methotrexate hepatotoxicity in children with leukemia.

Abstract

Percutaneous liver biopsy was performed on seven children with acute lymphocytic leukemia who had received maintanance chemotherapy with high-dose intravenous methotrexate for 1 1/2 to 2 1/2 years. Portal fibrosis was found in four of the seven children and in an additional patient treated with oral methotrexate. Serial tests of liver function and 99mtechnetium-sulfur-colloid scans did not accurately identify children with hepatic fibrosis. Clinical evidence of liver disease was not seen.

PMID:
870655
[Indexed for MEDLINE]
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