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Nat Med. 1996 Aug;2(8):906-11.

Large clonal expansions of CD8+ T cells in acute infectious mononucleosis.

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Molecular Immunology Group, John Radcliffe Hospital, Headington, Oxford, UK.


Primary infection with Epstein-Barr virus often results in the clinical syndrome of acute infectious mononucleosis (glandular fever). This illness is characterized by a striking lymphocytosis, the nature of which has been controversial. We show that large monoclonal or oligoclonal populations of CD8+ T cells account for a significant proportion of the lymphocytosis and provide molecular evidence that these populations have been driven by antigen. The results suggest that the selective and massive expansion of a few dominant clones of CD8+ T cells is an important feature of the primary response to this virus.

[Indexed for MEDLINE]

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