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Allerg Immunol (Paris). 1996 Feb;28(2):48-51.

[Platelet antigens: immunology and immuno-allergology].

[Article in French]

Author information

1
Servico de Medicina III, Hospital de Santa Maria, PropedĂȘutica MĂ©dica, Faculdade de Medicina de Lisboa, Centro de Immunologia e Hematologia da Universidade de Lisboa, Portugal.

Abstract

Platelet immunology allows the understanding of clinical findings in a genetic and serologic basis. Blood platelets bear common antigens and same specific antigens, classified in five groups (HPA 1 to 5), that are localized on membrane glycoproteins Ia, Ib alpha, IIb and IIIa. Antiplatelet autoimmunization is generally due to IgG antibodies against membrane complexes IIb/IIIa or Ib/lX. Antiplatelet alloimmunization, clinically resulting in Posttransfusion Purpura and Neonatal Thrombocytopenia is more frequently associated with anti-IIb/IIIa antibodies, either anti-HPA-1a or HPA-1b. Finally, platelet participation in immunoallergic reactions is discussed, focusing both platelet activation by allergen itself and platelet recruitment by other inflammatory cells.

PMID:
8703309
[Indexed for MEDLINE]

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