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Trends Biochem Sci. 1996 Apr;21(4):134-40.

The S100 family of EF-hand calcium-binding proteins: functions and pathology.

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  • 1Department of Pediatrics, University of Zurich, Switzerland.


Calcium lons as second messengers control many biological processes, at least in part, via interaction with a large number of Ca(2+)-binding proteins. One class of these proteins shares a common Ca(2+)-binding motif, the EF-hand, Here, we describe some functional aspects of EF-hand proteins, which have been found recently in different cellular compartments. Novel links between EF-hand proteins, particularly S100 proteins, and specific diseases are now emerging.

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