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Trends Biochem Sci. 1996 Apr;21(4):122-6.

Post-translational protein translocation: not all hsc70s are created equal.

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Department of Biological Sciences, University of Pittsburgh, PA 15260, USA.


Hsc70s in the yeast endoplasmic reticulum (ER) and mitochondria interact with membrane-associated components of the translocation machinery and are required for post-translational protein import. Although it has been proposed that the mitochondrial and ER machines function similarly, a variety of experiments suggest that BiP, the ER hsc70, might play a more elaborate role.

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