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Toxicol Lett. 1996 Sep;87(1):19-24.

Antagonistic effect of melatonin against cyanide-induced seizures and acute lethality in mice.

Author information

1
Institute of Community Medicine, University of Tsukuba, Ibaraki, Japan.

Abstract

The effect of melatonin on potassium cyanide-induced neurotoxicity was investigated in vivo. The ED50 value of potassium cyanide, as measured by induction of tonic and clonic seizures, was significantly increased by 1.5- or 1.8-fold by s.c. preinjection of melatonin (20, 100 or 345 mg/kg) in mice. The preventive effect of melatonin against potassium cyanide-induced seizures was dose dependent. The LD50 value of potassium cyanide, based on 24-h mortality, was also significantly increased by 1.3-fold by preinjection of melatonin. Potassium cyanide (8 mg/kg, s.c.) increased lipid peroxidation in whole brain of mice, and the increased lipid peroxidation was completely abolished when cyanide-induced seizures were stopped by preadministration of melatonin. These results suggest that melatonin, a pineal hormone, may protect against cyanide-induced neurotoxicity with its free radical scavenging effects in mice.

PMID:
8701440
DOI:
10.1016/0378-4274(96)03671-5
[Indexed for MEDLINE]

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