Format

Send to

Choose Destination
Nature. 1996 Aug 8;382(6591):511-7.

Cdc25 cell-cycle phosphatase as a target of c-myc.

Author information

1
Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, New York 11724, USA.

Abstract

The product of the proto-oncogene c-myc, in partnership with Max, forms a transcription factor that can promote either oncogenic transformation or apoptosis. The Myc/Max heterodimer binds to elements in the cdc25A gene and activates transcription. Like myc, cdc25A, itself a proto-oncogene, can induce apoptosis in cells depleted of growth factor, and Myc-induced apoptosis also requires cdc25A. These findings indicate that cdc25A is a physiologically relevant transcriptional target of c-myc.

PMID:
8700224
DOI:
10.1038/382511a0
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center