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J Leukoc Biol. 1996 Jul;60(1):1-7.

The nerve growth factor/tumor necrosis factor receptor family.

Author information

1
Department of Medicine, School of Medicine, University of California, San Diego, USA.

Abstract

Receptors in the nerve growth factor/tumor necrosis factor receptor family are characterized by the presence of cysteine-rich motifs of approximately 40 amino acids in the extracellular domain. The ligands are type II transmembrane proteins with beta-strands that form a jelly-roll beta-sandwich. The receptors recognize soluble or cell-surface-bound ligands and mediate diverse cellular responses. Activation of intracellular signals is mediated at least in part by the association of proteins with a RING finger motif or a death domain to the cytoplasmic domains of the receptors. In addition to cell-membrane-bound receptors soluble forms have been described for most of the receptors. Activation of intracellular signals not only occurs through ligand binding to the receptors but cross-linking of at least some members of the ligand family can regulate cell functions.

PMID:
8699112
DOI:
10.1002/jlb.60.1.1
[Indexed for MEDLINE]

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