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Ginecol Obstet Mex. 1996 Apr;64:177-83.

[Hereditary antithrombin III deficiency. Report of an obstetric case and review of the literature].

[Article in Spanish]


This case is a gravida 2, para 1, 21 years old, with a 36 weeks pregnancy, complicated with light toxemia, hereditary Antithrombin III (AT III) deficiency, and left iliofemoral thrombophlebitis; the patient was in labor. Two family members had thromboembolic phenomena, one of them had died because of this. The patient have had thrombophlebitis in both lower limbs during the puerperium of her previous delivery. She had received anticoagulants irregularly. Four months before the diagnosis of hereditary AT III deficiency, by laboratory. Labor was normal and had an eutocic delivery, masculine product, 3,250 g, without complications. Three hours before the effect of heparin had been reverted with protamine sulphate. Eight hours after delivery administration of heparin, was reestablished. The patient did not present other complications, and was discharged nine days after delivery. The literature about this subject was reviewed. Special emphasis is given to treatment alternatives in this type of disease that produce hypercoagulability and thromboembolic phenomena. This is the first report in Mexican literature.

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