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Curr Opin Struct Biol. 1996 Feb;6(1):18-23.

Mechanisms and uses of hydrogen exchange.

Author information

1
Johnson Research Foundation, Department of Biochemistry & Biophysics, University of Pennsylvania School of Medicine, Philadelphia 19104-6059, USA. walter@hx2.med.upenn.edu

Abstract

Recent work has largely completed our understanding of the hydrogen-exchange chemistry of unstructured proteins and nucleic acids. Some of the high-energy structural fluctuations that determine the hydrogen-exchange behavior of native macromolecules have been explained; others remain elusive. A growing number of applications are exploiting hydrogen-exchange behavior to study difficult molecular systems and elicit otherwise inaccessible information on protein structure, dynamics and energetics.

PMID:
8696968
PMCID:
PMC3412065
[Indexed for MEDLINE]
Free PMC Article

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