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Mutat Res. 1996 Jul 5;354(1):123-8.

Alterations of c-fos gene methylation in the processes of aging and tumorigenesis in human liver.

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Department of Radiation Research, Tohoku University School of Medicine, Sendai, Japan.


The state of DNA methylation in the c-fos gene was examined in human livers of different ages, cirrhosis and hepatocellular carcinoma. The degree of methylation in the intron 1 to exon 4 region increased with age, whereas all of the 10 cirrhosis samples revealed a decrease in methylation when compared to normal livers of similar ages. The 11 hepatocellular carcinomas showed varied alterations suggesting that the alteration of the c-fos gene methylation is related to aging as well as to early-step of hepatocarcinogenesis.

[Indexed for MEDLINE]

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