Format

Send to

Choose Destination
Biochem Biophys Res Commun. 1996 Jun 25;223(3):643-9.

Macrophage cytotoxicity against murine meth A sarcoma involves nitric oxide-mediated apoptosis.

Author information

1
Institute of Medical Biology, University of Tromsø, Norway.

Abstract

We have studied the cytotoxic effect of stimulated macrophages on Meth A tumor cells in vitro. When stimulated with interferon-gamma and soluble beta-1,3-D-glucan, macrophages exerted cytotoxicity towards syngeneic Meth A tumor cells. This cytotoxicity was associated with a high level of nitric oxide production. Both cell death and nitric oxide production were significantly inhibited by the addition of aminoguanidine, a specific inhibitor of inducible nitric oxide synthase (iNOS), to the culture medium. The cytotoxic effect was accompanied by internucleosomal cleavage of DNA as shown by electrophoresis and DNA fragmentation assay.

PMID:
8687449
DOI:
10.1006/bbrc.1996.0948
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center