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FEBS Lett. 1996 Jun 24;389(1):84-7.

Sequencing and functional analysis of the genome of Bacillus subtilis strain 168.

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Department of Microbiology, School of Microbiological, Immunological and Virological Sciences, Medical School, University of Newcastle upon Tyne, UK.


The international programme to sequence the 4.2 Mb genome of Bacillus subtilis, a model Gram-positive bacterium, is a joint project involving European, Japanese and US research groups. To date ca. 3.0 Mb of the genome has been sequenced, with the remaining 1.2 Mb expected to be completed in 1997. The amenability of B.subtilis to genetic manipulation, combined with the availability of extensive expertise on its biochemistry and physiology, makes this bacterium a valuable organism in which to investigate the properties of genes for which functions cannot be readily ascribed by standard methods.

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