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Curr Opin Pediatr. 1996 Feb;8(1):33-41.

Bone marrow failure in children.

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Jack and Lucy Clark Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029, USA.


Bone marrow failure in the pediatric patient places the hematologist at the junction of clinical medicine, cellular biology, and molecular genetics. The pathophysiology of these disorders is rapidly being elucidated in many laboratories. Treatments such as bone marrow transplantation and the nascent modality of gene therapy are firmly grounded in these modern sciences. This year's progress in the understanding, diagnosis, and treatment of a wide variety of predominantly pediatric bone marrow failure states is a direct result of the union between the "laboratory bench and the patient bedside."

[Indexed for MEDLINE]

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