Format

Send to

Choose Destination
Curr Opin Immunol. 1995 Dec;7(6):804-11.

The regulation of self-reactive B cells.

Author information

1
Howard Hughes Medical Institute, Stanford University School of Medicine, California 94305, USA.

Abstract

Self-reactive B cells are eliminated in a series of checkpoints that are triggered by antigen binding. Recent reports have shown that in addition to the processes of elimination at the immature B-cell stage, B-cell anergy and regulation of T-cell help, self-reactive cells are also controlled by follicular competition, Fas-mediated elimination by T cells and censoring in the germinal centres. Each checkpoint operates at a threshold that reflects the need to maintain immune diversity at the same time as suppressing autoimmune disease. Analysis of the motheaten mutation has given a direct demonstration of how such thresholds can be modulated by genetic effects.

PMID:
8679124
DOI:
10.1016/0952-7915(95)80052-2
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center